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KMID : 0980220140140030151
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Journal of the Korean Dental Society of Anesthesiology
2014 Volume.14 No. 3 p.151 ~ p.155
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Effect of Age on Optimal Clinical Dose of Dexmedetomidine Sedation
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Choi Yoon-Ji
Baik Jae-Won
Ro Young-JIn
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Abstract
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Background: Dexmedetomidine is known to be administered for sedation safely even in a very elderly patient. The purpose
of this study was to determine the effect of age on clinically optimal dose of dexmedetomidine for sedation.
Methods: We enrolled 50 patients ASA class I and II, scheduled for lower extremity surgery that need. They were classified into a young group (n = 26), aged below 75 and an old group (n = 24), aged above 75. Dexmedetomidine was continuously infused 0.5 μg/kg within 10 min, followed by maintenance at a dose of 0.5 μg/kg/min, initially. The next dose was selected using the Dixon’s up-and-down method.
Results: The cED50 of dexmedetomidine required to maintain optimal sedation level in young and old group were 0.50 and
0.48 μg/kg, respectively. With isotonic regression, cED95 of dexmedetomidine was 0.71 μg/kg (95% confidence intervals 0.57-1.06μg/kg) and 0.58 μg/kg (95% confidence intervals 0.51-0.67 μg/kg). There were no significant differences in cED50 (P = 0.21), recovery variables, or incidence of side effects between the two groups.
Conclusions: Clinically optimal dose of dexmedetomidine was not affected to the age during sedation.
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KEYWORD
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Dexmedetomidine, Elderly, Sedation
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